Nanotechnology

Optogenetics

Bioconjugation

Nanobiophotonics

Brain Machine Interface(BMI)

a) Multichannel-Neural Interfacing Implantable Microsystem

   Recording neuronal activity are fundamental in the neuroscience research as well as in the neural prosthetic systems enabling the treatment of neurological diseases and the restoration of sensory and motor disabilities. For these purpose, the neural interfaces have been developed for decades to make a connection between the nerve systems and the external systems. The purpose of this study is to develop a high-performance neural interface microsystem that is implanted in the brain and provide neural information for decoding brain functions. Ultralow power consumption is pursued so that the results of this study would be used for pre-clinical and clinical applications with wireless power transfer system.

Figure 1. Schematics of the dual panel brain implantable microsystem

 

Figure 2. (a) (b) (c) The picture of manufactured microsystem

b) Wirelessly Powered Microsystem

    Recording through subcutaneously wired Multi-electrode array(MEA) has revealed a plenty of knowledge about brain and neural signal decoding for a decade. However, subcutaneous connections impose limitation to behavior of subjects and raise great risks of infections. In order to overcome those limits, a lot of research teams have tried to develop microsystem which is able to record and process neural signals and small enough to be implanted underneath skull. In this microsystem, it is crucial to transfer stable and enough power wirelessly avoiding excessive tissue heating.

Figure 3. Realized microsystem powered by RF

c) Micro-Electrode Array(MEA) in BMI system

  In order to record brain signal, researchers have used non-invasive electrode such as EEG, fMRI or MEG that do not need delicate surgery. However, non-invasive method is insufficiency to get accuracy signal from brain. For the reason, researchers start to take invasive method even it needs to open the skull for penetrating electrode to brain. To minimize the risk of invasive electrode, many researcher teams consider to design micro-size, shape and thin probe, flexible substance and 3D array to get multi signal from variety points. Furthermore, the material of electrode should be bio-compatibility and non-toxic as electrode penetrates to brain. Material and design of electrode are main focus to study, some teams are studying integrated micro-electrode array with optics

 

Figure 4. Schematics of micro-electorde array (MEA) and optical MEA

 

 

 

 

Nano-Neuro-Photonics-Laboratory

Graduate School of Convergence Science and Technology, Seoul National University

D-509, 864-1, lui-Dong, Yeongtong-Gu, Suwon, Gyeonggi-Do, Korea, Postal Code 443-270

TEL :+82-31-888-9142, FAX : +82-31-888-9148